Environmental Factors Allowing Stem Cells from Skeletal Muscle Turning into Cardiac Muscle Like Spontaneous Beating Cells
نویسندگان
چکیده
منابع مشابه
Skeletal muscle stem cells
Satellite cells are myogenic stem cells responsible for the post-natal growth, repair and maintenance of skeletal muscle. This review focuses on the basic biology of the satellite cell with emphasis on its role in muscle repair and parallels between embryonic myogenesis and muscle regeneration. Recent advances have altered the long-standing view of the satellite cell as a committed myogenic ste...
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The ability to repeatedly regenerate limbs during the entire lifespan of an animal is restricted to certain salamander species among vertebrates. This ability involves dedifferentiation of post-mitotic cells into progenitors that in turn form new structures. A long-term enigma has been how injury leads to dedifferentiation. Here we show that skeletal muscle dedifferentiation during newt limb re...
متن کاملPerspectives: Cardiomyocytes from Skeletal Muscle Stem Cells for Cardiac Repair
Heart failure is a major contributor to mortality in the United States. Many cardiomyocytes (CM) die following myocardial insult, and the post-natal mammalian heart has very limited regenerative capacity. Heart organ transplantation is a final therapeutic option to prevent patient death when heart failure is imminent. However, donor organ availability cannot completely meet current demands, and...
متن کاملSkeletal muscle-derived stem cells differentiate into hepatocyte-like cells and aid in liver regeneration.
The liver is unique for its ability to regenerate after injury, however, critical injuries or disease cause it to lose this quality. Stem cells have been explored as a possibility to restore the function of seriously damaged livers, based on their self-renewability and multiple differentiation capacity. These experiments examine the ability of muscle derived stem cells (MDSCs) to differentiate ...
متن کاملRepairing skeletal muscle: regenerative potential of skeletal muscle stem cells.
Skeletal muscle damaged by injury or by degenerative diseases such as muscular dystrophy is able to regenerate new muscle fibers. Regeneration mainly depends upon satellite cells, myogenic progenitors localized between the basal lamina and the muscle fiber membrane. However, other cell types outside the basal lamina, such as pericytes, also have myogenic potency. Here, we discuss the main prope...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2015
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2014.11.1436